Ankur Gupta, Ph.D.

We make numerous decisions (some involving movements and others not) each day that often involve integrating the information from various sensory systems. This information is processed by various subsystems that specialize in specific aspects of processing, such as the visual system for vision; basal ganglia in learning and error correction; motor areas in movement; and hippocampus in memory storage and recall. This complex and highly distributed network processing involving numerous areas poses a significant challenge in understanding brain function and consequently considerably limits interventions for motor/cognitive impairments and neurological disorders. 

 

My long-term goal is to understand the communication both within and between various brain areas and modulate this communication to restore/alter cognitive behavior at multiple levels (computational, single neuronal activity, and population activity). 

 

Toward this goal, I developed a computational model for grip force changes in Parkinson's disease patients. I later probed neuroplastic changes in the motor cortex of behaving primates.

 

I am currently studying the theta-gamma oscillations between the large-scale distributed brain networks comprising the hippocampus, entorhinal cortex, and prefrontal cortex during an episodic memory task. Furthermore, I am exploring the effect of hippocampal and entorhinal cortex neurostimulation on task performance. These areas were precisely (with submillimeter accuracy) implanted with sEEG electrodes using a state-of-art neuronavigation system, a high-resolution MRI, and CT (manuscript under preparation). Lastly, in this project, I also aim to restore cognitive performance by using a combination of the drug scopolamine (to induce memory deficits similar to aging-related cognitive decline) and neurostimulation.

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email:ankur.gupta[AT]u-bordeaux.fr
NeuroDTx Team website

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(Last update 23 October 2024)